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Despite the substantial obstacles to ARV adherence, motivation to adhere was extremely high in our study, consistent with previous studies.
Though we nod when Gordon-Reed observes that "despite some very real and substantial obstacles, James Hemings's soul had a much greater chance to flourish in Paris than in his native country," it is difficult to speak confidently about the state of someone's soul.
Still, he faces substantial obstacles.
Ms. Bachmann would have substantial obstacles to overcome.
That may well be the case for Mr. McCain too, and he faces substantial obstacles.
But Pentagon officials have said there are substantial obstacles to any such sales.
So, interest-group politics commonly produce substantial obstacles to reform of corporate governance.
"They may pull through," said Patrick Finnegan, a senior vice president at Moody's Investors Service, "but they face substantial obstacles".
The US supreme court has ruled that states may not place undue burdens or substantial obstacles to women seeking abortion.
Substantial obstacles lie in the way.
Mexía overcame substantial obstacles, including emotional instability, to pursue her love of plants.
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CEO of Professional Science Editing for Scientists @ prosciediting.com