Sentence examples for despite substantial efforts from inspiring English sources

Despite substantial efforts to develop therapeutics targeting this pathway4,5, significant challenges still exist.

Despite substantial efforts invested, there exists a crucial need to establish a comprehensive model for reliable estimation of such evolution.

Over that period, the share of public transport in urban agglomerations has either been constant or declining in almost all cities in the world, despite substantial efforts to support its growth.

Despite substantial efforts at control over several decades, malaria is still a major global health problem as chemotherapy of malaria parasites is limited by established drug resistance and lack of novel treatment options.

Resurgence of nuisance benthic algae in the Great Lakes, despite substantial efforts to reduce phosphorus loading, has stimulated renewed interest in exploring the diverse drivers of near-shore water quality.

Despite substantial efforts, type II diabetes mellitus (T2DM) remains a major contributor to the world's morbidity and mortality [1, 2].

However, despite substantial effort, attempts to elicit oligomannose-specific antibodies with capacity to effectively neutralize HIV have not been successful4,5,6.

For example, while some PPI sites have led to potent small molecule inhibitors, others have not despite substantial effort [5], [6].

Many trials struggle to complete enrollment in a timely fashion despite substantial effort.

Not surprisingly, so far, despite substantial effort, traditional methods of phylogenetic analysis failed to yield a solution.

Despite substantial effort to decipher the etiology of the disease, the primary events triggering the pathology remain to be elucidated.