Despite significant local protest, Southampton approved the Rennert mansion.
Despite significant improvements in Iraq's security, rehearsals posed enormous difficulties.
went down to defeat despite significant support from Crossroads.
Despite significant logistical complications, Palin wanted to oblige them.
Despite significant advances in immunology and microbiology, the United States lags in developing new vaccines.
Despite significant support from his own caucus, the Senate majority leader, Mitch McConnell, has been noncommittal.
Doctors worked for about an hour to revive him despite significant blood loss.
Despite significant gains, blacks are still scoring about 200 points below whites on College Boards.
Despite significant representation in the Stem fields, religion can serve as a spectre.
Despite significant gains recently, the median male worker has fared poorly since the 1970's.
Despite significant use of generic drugs, however, costs have soared and outstripped revenues.
