Sentence examples for despite receptor from inspiring English sources

About half of resistant tumors develop T790M secondary mutations in EGFR which prevent an effective inhibition by EGFR TKIs [6, 7] whereas an additional 15 20 % of tumors undergoes amplification of MET receptor tyrosine kinase [8] which causes a lateral activation of EGFR signaling cascade despite receptor inhibition.

The soluble ectodomain of TRAIL also assembles into trimeric molecules but is in contrast to the membrane-bound molecule poorly active despite receptor binding.

Thus, despite receptor specific binding and good metabolic stability, the tumor uptake was low and the radioactivity concentration in urine as well as gall bladder was very high, indicating both renal and hepatobiliary elimination making this compound not suitable for imaging integrin α v β6 expression.

However, in vivo SPECT images showed substantial heterogeneous radioactivity accumulation despite homogenous receptor distribution in the tumor xenografts as assessed by in vitro autoradiography.

However, the influence of these heterogeneities on cellular signaling remains elusive despite uncontrolled receptor signaling being implicated in various forms of cancer.

Despite high receptor expression and homogenous receptor density in our model, assessed by biodistribution and in vitro autoradiography [21], high-resolution in vivo SPECT imaging revealed non-uniform uptake patterns of radioactivity within tumor tissue [20, 22, 23].

A possible explanation of a lack of a protective effect of GDNF on neurons from AL-fed animals despite maintained receptor expression is that downstream signalling or other pathways may be disrupted or impaired in neurons from ageing AL-fed animals.

For uninfected cells (Figure 6A) there is no IFNB1 induction despite increasing receptor binding.

Despite the receptor's homeostatic and protective functions during the acute phase of lung injury [38], [50], several studies have shown that signaling through the A2BR can contribute to the pathology and progressive nature of chronic lung diseases [20], [30], [39].

Interestingly, CX3CL1 had no chemotactic effect on these cells, despite robust receptor expression and in contrast to previous reports.

Secondly, it is possible that PRL influences canine mammary tumorigenesis despite decreasing receptor expression, via alterations in signaling pathways.