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Overall, sagopilone was quite well tolerated, with neurotoxicity being the most prominent side-effect despite prolongation of the infusion time.
When observing and diagnosing the thrombotic process, it is important to understand how increased coagulation is occurring despite prolongation of PT/aPTT.
However, this target population could not be achieved despite prolongation of the recruitment period and expansion of the number of participating centres.
These effects were at variance from d-sotalol, a selective IKr blocker, despite prolongation of action potential duration and the QT interval of the in-vitro-modelled electrocardiogram by both drugs.
They also found that despite prolongation of AH and VA intervals, Wenckebach point, and AV nodal effective refractory period in the immediate post-operative period, all these variables normalized by 14 days after surgery except for the AH interval.
However, the proportion of pregnant women who did not attend AE did not exceed 7.3% of participants despite prolongation of the recruitment period from 4 to 8 months, while 92.6% of nulliparous pregnant women attended AE.
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Despite significant prolongation of the QTc, no patient developed torsades de pointes (TdP), ventricular tachycardia (VT) and/or ventricular fibrillation (VF).
However, despite PT prolongation, patients with cirrhosis seldom exhibit clinical bleeding events; hence, the PT may not accurately reflect the global hemostatic activity affected by various decreased levels of pro- and anticoagulation factors in cirrhosis.
Despite a prolongation of arthritis, co-transfer of the CII-specific T cell line with the monoclonal antibodies did not alter the acute phase of antibody-mediated disease into a chronic disease course, suggesting the importance of other cellular mediators in the pathogenesis of arthritis.
Despite the QT prolongation associated with AF-cardioversion, torsade de pointes was not observed.
Despite observed QT prolongation with sertindole, there were no recorded cases of torsades de pointes in this survey.
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