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Despite opposite effects on apoptosis and wide differences in amino acid sequences, three-dimensional structures and secondary structure predictions suggest that the protein fold is conserved within the 'multidomain' subfamily.
Despite opposite effects of MsmR on the polarity of pilus gene expression in nra-positive versus rofA-positive Alab49 strains, MsmR is a strong activator of prtF2 gene expression in both genetic backgrounds.
However, despite opposite effects of rSLURP-1 and -2 on lateral migration of KCs in the AGKOS assay, simultaneous inhibition of auto/paracrine functions of SLURP-1 and -2 in skin wounds with a mixture of anti-SLURP-1 and -2 antibodies delayed epithelialization even more than the anti-SLURP-2 antibody given alone.
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In fact, here again effects of Ssa3p and Ssa4p were indistinguishable despite their opposite effects on [PSI+].
Despite these opposite effects, however, the combination of HDACis and endocrine therapy acted synergistically in ER-positive models [ 34].
Despite the opposite effects of attention and surround stimulation, their effect at the single cell level was still correlated, i.e. attentional MIs and surround MIs often showed a positive correlation.
These observations indicated that despite their opposite effects on lateral migration of KCs, auto/paracrine functions of SLURP-1 and -2 during the cutaneous stress response to wounding extend beyond regulation of keratinocyte motility.
It remains an intriguing conundrum why Noonan and Leopard syndrome mutations result in partly similar pathologies despite their quite opposite effects on SHP2 catalytic function [ 45].
Indeed, studies in yeast reported that shortening or delaying CHK1 activation results in cellular hypersensitivity to DNA damage despite an opposite effect on mitotic entry (9).
Additionally, it is noteworthy that ACEI, angiotensin receptor blockers and statins – despite improving NO bioavailability – exert opposite effects on the risk of new-onset type 2 diabetes [ 59, 60].
Retention tests revealed opposite effects on fear expression despite identical behavioral treatments: intra-hippocampal DCS inhibited fear expression while intra-amygdala DCS potentiated fear expression.
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