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Despite of major advances in the current understanding of Parkinsonism pathology, the exact mechanism involved in this neurodegenerative cascade remains unclear.
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A new service that would make major blockbusters available at home on the same day they hit cinemas has been proposed by the Napster founder, Sean Parker, despite reports of major misgivings in Hollywood.
Despite months of major fluctuations in the Chinese stock market, Apple still managed to have an outstanding quarter in China.
Most mobile money systems only operate within the boundaries of a single country, despite evidence of major trade and remittance corridors existing across national borders.
Although the species has recovered from that low point, the breeding population in 1999 was 30% below the long-term average, despite years of major efforts focused on restoring the species.
However, the impact of domestication on pathogenicity traits has rarely been investigated, despite being of major importance to understand the consequences of modern human activities on disease emergence.
Despite absence of major clinical side effects a potential risk remains that transplantation of MSC may harbor some tumorigenic potential - especially in autologous transplant settings.
Despite induction of major global histone acetylation and putative enhanced DNA accessibility, the induced promoters showed high site specificity with regard to TSSs.
Despite indications of major histocompatibility complex loss and HLA class I downregulation by ALL cells no recent attempt has been made to establish the baseline contribution of heritable major histocompatibility complex variation to the clinical outcome of childhood ALL.
Clinical issue Despite elucidation of major factors involved in the progression of chronic kidney disease (CKD) and development of better treatments, the number of individuals with end-stage kidney disease (ESKD) that require renal replacement therapy is steadily increasing.
My article on John focused on how he'd just been stripped of part of his disability benefits and been deemed fit to work – despite a series of major injuries, despite constant pain and sleeplessness, despite very limited mobility.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com