In the current global crisis, Europe has been much criticized for a slow response and — despite large efforts by individual nations — the lack of a giant collective stimulus in the 27-nation EU.
Despite large efforts to solve this problem the methodological situation appears unsettled to a large extent and the "quest for orthologs" is still an ongoing task in large-scale genome comparisons.
Therefore, despite large efforts, variations in tumor size distribution between groups were inevitable, although no statistically significant difference in tumor volume was seen between any of the treatment groups before treatment start.
Despite large efforts carried out on passive solar distillation, there are some challenges like bulkiness, high initial cost, and optimization of spacing between condensing cover and water surface of inclined still, thermophysical properties of basin material, flow rate, insulation material and its thickness, which need to be improved to make this technique efficient in practical utilization.
Despite large efforts to find out how to treat memory and learning impairments, treatment remained either in part or in whole ineffective.
However, despite large efforts in the past decade, the (in efficiency of enzymatic hydrolysis of lignocellulosic materials remains a key limiting step in many biorefining approaches [ 4].
Mutations in the known high-risk genes BRCA1, BRCA2, p53, ATM and PTEN account for less than 25% of the familial risk for breast cancer while the remainder are still genetically unexplained despite large efforts in research [ 1].
However, despite large efforts to identify SNPs in genes previously identified as candidates for cancer susceptibility, genome wide identification and characterization of SNPs among cancer patients or tumor tissue has not been reported.
An 'average' lipid made up of unsaturated C18 fatty acids and a glycerol head group was assumed based on the largest percentage of lipids being C18 as reported by Janero and Barrnett [ 38] and is shown in reaction 179 in additional file 2. Despite large efforts to fully annotate genome databases, not all enzymatic functions are listed and therefore gaps exist in the pathways.
Franklin D. Roosevelt died after a stroke in 1945, despite a large effort by his physicians to control his very high blood pressure by prescribing sedatives and rest.
