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The fact that STR was removed despite its conservation pattern that would be expected to allow it to pass through our filtering approach [ 22], can be explained with the fact that it is part of a large gene family (ABC transporters).
Despite its conservation, there are no functional or expression data available in the literature.
Thus, a Gly at position 69 does not commit a SOD to use of Mn despite its conservation in MnSODs.
Despite its conservation, K336 is not essential for catalysis since mutations at this position did not destroy the activity.
Despite its conservation in all eukaryotes, comprehensive analyses of Drosophila core promoters as well as mammals have suggested that the TATA occurs in approximately 10 30 % of all genes within a genome [ 6, 7, 19, 34, 35].
One example of such avirulence-based host specificity is the loss of AVR1-CO39 in all rice isolates, despite its conservation in all nonrice isolates (Cesari et al. 2013).
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Despite of its conservation status, fecal and agrochemical pollution are in levels considered dangerously high for humans.
It was hence concluded that despite its strict conservation and unique modification, the diphthamide histidine appears not to be essential to the function of human EF-2 in protein synthesis.
The role of ARSD is unknown and it has no demonstrated sulfatase activity despite its high conservation of the N-terminal domain important for catalytic sulfatase activity [ 35].
Despite its high conservation, a BLAST search of the intracellular domain alone did not identify strong similarities with domains in other proteins.
Despite its functional conservation, the mitochondrial genome (mtDNA) presents strikingly different features among eukaryotes, such as size, rearrangements, and amount of intergenic regions.
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