Despite increased understanding of the genetic and epigenetic aspects of AML, the outcome for AML patients has not changed significantly.
Despite increased understanding of its pathophysiology, our ability to prognosticate in individual patients with severe sepsis is poor.
4 Despite increased understanding of the factors contributing to the development of chronic pain, 5 there has been little improvement in how successfully it is treated and managed.
DOI: http://dx.doi.org/10.7554/eLife.07616.002 Despite increased understanding of infectious disease ecology and dynamics, recent decades have seen an upsurge in the emergence and re-emergence of multiple infectious diseases (Jones et al., 2008).
Despite the increasing understanding of the immune responses behind the formation and maintenance of the granulomatous process in sarcoidosis, its etiology remained elusive.
Despite an increasing understanding of the molecular heterogeneity of TNBC, clinical trials of targeted agents have thus far been disappointing; chemotherapy, in particular with anthracycline and taxanes, remains the backbone medical management for both early and metastatic TNBC.
Despite our increasing understanding of the biochemical and cell biological functions of different co-chaperones, we know very little about how coordinated alterations of multiple components of the co-chaperone network could lead to dynamic adaptations of the proteostasis machinery.
Despite our increasing understanding of dementia, particularly AD, no current known preventive or curative measure exists.
Despite the increasing understanding of female reproduction, the molecular diagnosis of primary ovarian insufficiency (POI) is seldom obtained.
Despite the increasing understanding of female reproduction, defined causes or mechanisms resulting in primary ovarian insufficiency remain largely unknown [ 7].
