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Despite increasing knowledge of turbidity current triggers, the down-canyon variability in turbidity current frequency within most canyon systems is not well constrained.
Despite increasing knowledge of the genetics and biochemistry of NP-C, convenient, easily applied diagnostic methods are lacking.
Despite increasing knowledge of the processes underpinning liver disease progression, it is still not possible to predict which patients will progress and which will experience minimal fibrogenesis.
Despite increasing knowledge of replication and packaging of HEV in somatic cells, an efficient cell culture method is currently not available (38, 39 ).
Despite increasing knowledge of the closeness of human and animal destiny, the "mutual obligation" so clearly defined by Charron is slow to advance.
Despite increasing knowledge of attention deficit hyperactivity disorder (ADHD) across the life span, there is still little research on adults' own experiences of being diagnosed with ADHD.
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Despite increasing knowledge on histological categorization of serrated polyps (SPs) data are lacking on the actual prevalence and the association of each SP subtype with advanced colorectal neoplasia.
Despite increasing knowledge on the spatio-temporal dynamics of river temperature, a master water quality variable, it remains a challenge to identify the landscape variables influencing thermal heterogeneity along entire river courses.
Despite increasing knowledge on VTE, various clinical aspects of the disease are still unclear and advancements in diagnostic tools and medical therapy generate new unknown issues and uncertainties.
6 Despite increasing knowledge on VTE over the past decades, there are still several aspects of diagnosis, clinical management, treatment and prognosis with uncertainties that need to be addressed.
Despite increasing knowledge on AD-associated pathology, the molecular mechanisms underlying the cause of sporadic and familial AD are still not completely understood.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com