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Despite important advances in our understanding of Notch signal transduction, the regulation of Notch functions in the nucleus remains unclear.
However, despite important advances in the field in the past three decades, several challenges associated with the biocompatibility are still remaining.
Despite important advances in tissue repair and regeneration over the past few decades, complete functional repair of damaged or diseased human tissues has remained elusive.
Despite important advances in the treatment of first-line chronic lymphocytic leukemia (CLL) over the past decade, CLL remains an incurable disease with significant unmet needs.
Despite important advances of longitudinal research in substance use behaviors, most studies stratify analyses by gender or race, which limits the ability to directly compare the likelihood of a particular developmental pathway across demographic groups.
Despite important advances in microvascular bioprinting, further work is required to enhance the interface of medical imaging and bio-CAD, optimize bioprinting systems, and accelerate the maturation process of bioprinted implants.
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Despite these important advances, a coherent global analysis of future ESLs that resolves all the above processes has yet to be conducted.
Despite these important advances, there are two criticisms about the use of the CPM's in DM: (i) Can this class of model reproduce severe basal glucose levels (e.g., larger than 300 mg/dl)? and (ii) Does a CPM reproduce a distinct glucose level as its parameters change or is it unique even if its parameters change?
Despite these important advances, known genetic variants explain <10% of the heritable component of disease, and little is known about their contribution to aetiology.
Therefore, despite these important advances, a clear explanation for the restriction of TCRα gene expression to T cells has remained elusive.
Despite these important advances, a simple, rapid, efficient and reproducible model to study mechanisms of AR function remains elusive; numerous separate biochemical techniques are still mandatory to facilitate any hope of interpolation that may provide a systems biology level appreciation of mechanisms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com