Despite the extensive progress made on α-pinene production in E. coli, many possible improvements can be achieved to enhance α-pinene production.
However, despite extensive efforts, little progress has been made to improve efficacy since the first introduction of a live, attenuated vaccine in 1994 in the USA.
Despite extensive research effort and progress, the pathogenesis of AD remains incompletely understood, partly due to highly complex and intertwined intercellular cross-talks taking place throughout the aging process [2].
Despite extensive efforts and the considerable progress made toward improving its detection and survival rates over the past few decades, the 5-year survival rate for pancreatic cancer has not changed significantly, increasing – according to data from surveillance, epidemiology and end results – from 3% in 1975 to only 5.4% in 2005 (see other reviews Conroy et al., Muller et al. and Poruk et al).
Despite extensive poverty and limited resources, in the last decade Ethiopia has made impressive progress in improving its health care system.
Only a small fraction of early drug programs progress to the market, due to safety and efficacy failures, despite extensive efforts to predict safety.
Following the development of the fictitious crack model (FCM) by Hillerborg and his colleagues for analyzing the cracking behavior of a single crack, less progress was made in extending the method to multiple-crack problems despite extensive research efforts.
However, despite extensive work over the past decade, computational determination of gene function has made only uncertain progress.
Despite extensive research over the last several decades, the mechanisms accounting for the rapidly progressing and destructive nature of PAM are still unknown.
Despite extensive criticism of this Constitution for its emphasis on the role of the military, much progress has been made towards constitutional government and law reform.
