Despite heroic (and expensive) efforts to keep up the numbers, circulation has fallen relentlessly.
Despite extensive, and expensive, efforts on several fronts to keep overheated New Yorkers from tampering with the city's 98,000 hydrants, people in neighborhoods across the city have managed to pry open hundreds of them on this summer's hottest days.
Despite considerable and expensive efforts the transparency of hospital quality and outcomes remains insufficient [ 22, 12].
Broadly speaking, the picture is one of a remarkable resilience in coca and cocaine production, despite enormous and hugely expensive efforts by governments to stamp it out.
Despite more than a decade of urban boosterism, beginning with sitcoms like "Friends" and "Sex and the City" and continuing with expensive efforts to spruce up downtown districts, the drift to the cul-de-sacs continues.
Despite a determined and expensive effort by the president's men to win over representatives from smaller parties, the Oranges got their choice as speaker, the third office in the land, when Kenneth Marende, a lawyer, squeaked in by 105 votes to 101.
In 1625 the charter of 1621 was renewed, but despite expensive and sincere efforts, including an offer of hereditary baronetcies to Scotsmen who established six or more settlers, by 1626 Alexander had failed to colonize the region, and there were only 28 baronets (the total reached 85 by 1631).
Despite an intense and expensive lobbying effort against it, all but four of Obama's fellow Democrats backed the nuclear pact between the United States, five other world powers and Tehran that was announced in July.
Less expensive Web efforts balance the sleek TV ads, for a total of almost 60 videos.
Poor schools have dreadful outcomes and tend to require expensive remediation efforts.
