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Inhibition of MTAP's enzymatic activity with a potent transition state inhibitor failed to significantly reverse any of the functional effects of MTAP expression, despite effectively inhibiting MTAP's enzyme activity in cell extracts and causing the accumulation of MTA.
Despite effectively terrorizing the enemy, Marshall's entire campaign was deemed a failure, and he resigned from the Confederate Army less than two months later.
4. The Siege of Krishnapur by JG Farrell For some reason, despite effectively winning the Booker prize twice, Farrell has never entered the popular imagination as one of the greats.
Belokon – who does not take a salary at Blackpool despite effectively running the club as a joint-partner with Owen Oyston, the owner since 1988, and Karl, his son – is worth an estimated £200m through his interests in finance, food and the media.
Lee et al. used a piezoelectric nozzle [20], which, despite effectively controlling the particle size, requires specialized equipment and many steps.
Despite effectively filling the injured Carmelo Anthony's role, it was he who suggested to coach Mike D'Antoni that Lin should play more.
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Despite their effectively identical DNA (in recent years, scientists have shown that even monozygotic twins generally have a small number of unique genetic mutations), the two men have taken contrasting courses and we want to find out why.
Despite pitching effectively in the first two innings, Maine ultimately allowed six runs on seven hits and walked three in just five innings, throwing 105 pitches and giving back a three-run first-inning lead.
Mayweather, on the other hand, was roundly booed, despite being effectively the house fighter.
Despite being effectively eradicated in the US as recently as 2000, a measles outbreak that started at the Disneyland amusement park in California has spread to 14 US states and infected at least 84 individuals.
The fact that many people living with chronic HIV are experiencing cognitive and neurological decline during mid-life and resembling the neurological functioning of older adults provides compelling evidence that premature cognitive aging is occurring despite cART effectively reducing HIV-associated morbidity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com