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However, despite discovery of these DNA polymorphisms, a significant gap exists in linking them to phenotypic traits so that they can be of more value in crop improvement as well as in genetic diversity analysis.
Despite discovery of the causal gene duplication in 1991, the first high throughput screen (HTS) targeting PMP22 was not published until 21 years later in 2012.
Overall, the TIGR sequence pseudomolecules show less discordance with our findings than the IRGSP sequence pseudomolecules as judged by comparison of in silico vs. optical mapping fragment masses and reduced prevalence of sequence misassemblies despite discovery of additional gaps within sequence assemblies.
This is despite discovery of a number of previously undescribed viruses since 2001 from clinical specimens from the human respiratory tract (human metapneumovirus [ 11], SARS coronavirus [ 12], coronavirus NL63 [ 13], coronavirus HKU1 [ 14], novel rhinoviruses [ 8], human bocaviruses [ 15] and K1 and WU polyomaviruses [ 16, 17]).
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Despite discoveries on many fronts, up to two-thirds of the grants either did not get renewed or may not in the near future, Mr. Gates estimated.
Despite discoveries and developments in osteotropic factors, therapies exploiting these macromolecules have been limited due to a lack of suitable delivery vehicles and three dimensional (3D) scaffolds that promote bone regeneration.
Despite discoveries such as Sedna, the region between the Kuiper belt and the Oort cloud, an area tens of thousands of AU in radius, is still virtually unmapped.
Despite discoveries that SYT and SSX associate with other nuclear proteins [2], [15] [21], it remains unclear how SYT/SSX might contribute to neoplastic transformation.
There are some tumors, though small when discovered, that are highly aggressive and may spread despite early discovery.
Sales held up despite the discovery in Washington State last month of a cow that was infected with mad cow disease.
Despite the discovery of mad cow disease in the United States last week, executives at the Burger King Corporation have decided to go ahead with a new Whopper television campaign.
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