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This study highlights the substantial functional and emotional burden migraine exerts on individuals, as well as the significant unmet needs that remain for these patients despite currently available care and treatment options.
Despite currently available chemotherapeutic treatments and autologous transplantation resulting in an improvement in overall survival of patients, MM still remains incurable and the average prognosis is only three years to five years [2].
Cancer of the oesophagus presents symptomatically late in the course of the disease and, despite currently available therapies, carries a poor prognosis.
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Patients with superficial BC (70% of the urothelial carcinomas) have a relatively good prognosis, but patients diagnosed with invasive, high grade BC, and those who progress to invasive BC, have a poor prognosis and will not survive their disease in many cases due to their metastases, despite the currently available treatment options.
Despite the currently available regimens, therapeutic resistance remains one of the major challenges [ 4].
7 Despite the currently available evidence, in reality, initial combination therapy is not commonly used and formal prospective studies are required to catalyse change.
Despite the currently available data for chemotherapy in advanced CRC, there is still considerable variation in practice among the oncological community worldwide.
Despite that currently available oral hypoglycemic agents are able to target deficiencies in either the endogenous insulin secretion or the insulin sensitivity at different target sites, the attainment of satisfactory diabetes control becomes more and more difficult the longer the duration of the disease (9).
Despite accumulating data currently available regarding the machinery of mitochondrial fission and fusion, the precise molecular mechanisms are still not fully understood.
Finally, we describe the importance of designing effective interventions, despite the lack currently available, and suggest potential areas of future research.
Despite limitations of currently available data, this model represents a valuable tool in assessing the outcomes achieved by states and hospitals in caring for patients with pneumonia, and has been endorsed by the National Quality Forum as a measure for acute care hospital performance [29].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com