Despite considerable efforts, no essential cellular receptors for filovirus entry have been identified.
Despite considerable efforts to defend against exploits, automatic exploit diagnosis remains a significant challenge.
Despite considerable efforts, the spatial link between the nuclear architecture and the genome remains enigmatic.
Despite considerable efforts, a practical GnRH vaccine has yet to be developed for rams.
Despite considerable efforts, no long-term culture models for non-transformed pancreatic acini exist.
However, despite considerable efforts, early progress in treatment was slowed by lack of consistent definitions and appropriately powered clinical trials.
Mr. Pawlenty, despite considerable efforts, has simply not convinced very many Republicans that he should be their first choice.
Despite considerable efforts, the development of reliable chlamydial vaccines using conventional strategies has proven to be elusive.
Additional host factors in the endosomal compartment are probably required for viral membrane fusion; however, despite considerable efforts, these critical host factors have defied molecular identification.
Despite considerable efforts in resolving their evolutionary history and macroevolution, few studies have included a full phylogenetic diversity of gnathostomes, and some relationships remain controversial.
Despite considerable efforts, the Spanish navy was unable to suppress a contraband trade that, from the colonists' point of view, was a necessity.
