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In terms of the former, clinical data must have been insufficient as "despite best supportive care" the patient did not improve.
Despite best efforts, outbursts happen.
But despite best of intentions, we made very serious mistakes.
But despite best intentions they do not socialise off screen.
Despite best efforts, errata will be almost surely be discovered over time.
Despite best efforts from security API designers, flaws are often found in widely deployed security APIs.
Bankers are making fortunes despite best efforts to rein in bonuses.
While highlighting successful strategies, Esty and Winston also examine why environmental initiatives may fail despite best intentions.
He says we should all be prepared for the fact that despite best efforts it could happen again.
So many scenes feel a couple of drafts away from flying despite best intentions of the cast.
"This [dehydration] is a long term problem and despite best efforts by nurses sometimes it's very difficult to encourage or persuade someone elderly to drink", she said.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com