Sentence examples for despite activating from inspiring English sources

β-catenin induced a ∼30%% increase in colony formation in HCT116 and HepG2 cells, in consistency with data on cyclin D1 promoter activity, thus supporting the hypothesis that despite activating β-catenin mutations, cells can still respond to stimuli inducing further increases in β-catenin levels.

But not all went to plan as, despite activating his card two days earlier, he failed to get the green light from any of the bikes lined up ready to go.

This suggests that GLP-1 can facilitate the closure of the ATP-sensitive K+ channel despite activating ABCC8 mutation.

In contrast, Rac3 has minimal effect in MCF-7 cells under the same conditions, despite activating ERK.

However, despite activating T cells against AQP4, these rat and mouse models do not develop a clinical neurological phenotype either because pathogenic T cells responses are limited by a combination of central and peripheral tolerance or because certain AQP4 epitopes are not pathogenic.

However, CD28 ligation alone does not induce changes in glucose metabolism, despite strongly activating PI3K and Akt [12], [35], implicating TCR-initiated signaling in this process as well.

Despite knowing that activating the temple will accomplish Kerrigan's objectives, Zeratul and Artanis proceed with little other choice, wiping the Zerg off Shakuras' surface.

Fierro and Parekh found that SERCA pumps were remarkably effective in RBL-1 cells and could prevent ICRAC from activating, despite significant Ca2+ leakage from the stores [25].

Our data are again in good agreement with those of Parekh and his group who found that SERCA pumps were remarkably effective in RBL-1 cells and could prevent ICRAC from activating, despite significant Ca2+ leakage from the stores and a cytosolic Ca2+ binding ratio of between 2000 and 5000 (more than two orders of magnitude greater than within the stores) [25].

Despite being activated in response to cAMP, inhibition of ERK activity with the MEK inhibitors, 1 μM AZD6244 and 1 μM PD184352, had little effect on EPAC1-dependent cell spreading (Supplementary Fig. 5A and B) indicating that although ERK is a downstream target for cAMP signalling this occurs independently to the changes in cell morphology associated with activation of EPAC1.

Singh et al used RNAi to deplete the KRAS protein in lung and pancreatic cancer cell lines harbouring mutated KRAS alleles; this identified KRAS-dependent cells (which reacted to KRAS silencing with growth impairment) and KRAS-independent cells (whose proliferative activity was not affected by KRAS silencing, despite the presence of activating KRAS mutations).