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Despite achievement of complete clinical response, recurrence rates remain high.
Assessment of lactate clearance in the first 24 hours would be useful for tracking patients who remained at high risk of death despite achievement of recommended early goals determined by international recommendations.
No significant effect was seen in the GLAR-treated patients despite achievement of similar glycemic control.
In addition to joint damage, continuing impairment of physical function despite achievement of the targeted disease activity level may also necessitate a therapeutic change (category IV).
Another factor that indicates progression is an increase in albuminuria from stage A2 to A3 over time despite achievement of blood pressure goals (342).
Recent data, however, strongly suggest that concentrations of antibiotics reached in the interstitium of soft tissues might be ineffective in critically ill patients, despite achievement of adequate plasma concentrations [ 18].
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Despite achievements in the pilot phase, knowledge and use of medical abortion was very low.
An additional 20 25% of the patients develop metastasis during the course of disease and have a very poor prognosis despite achievements in multimodal therapy [ 1].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com