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The phrase "despair about" is correct and can be used in written English.
It means to feel hopeless or lacking in confidence about something. It is often used to express a strong feeling of sadness or discouragement. Example: Sarah couldn't shake off her despair about her failing grades, even though she had been studying diligently.
Exact(60)
But am I in despair about it?
We feel a kind of despair about our lives.
The whole episode makes you despair about making predictions.
It is easy to despair about the climate's prospects.
"I was in despair about it," she told me.
"Gilded Age politics induces pertinent despair about democracy," he writes.
I am in despair about the future of telecare.
Greed, he notes in a parenthesis, is "despair about pleasure".
In his York Road office he talks with thoughtful despair about the party he left.
But the despair about New York is longer and deeper than this election or recession.
Human rights advocates despair about Congo and say this election especially worries them.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com