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If desired, substitute apple juice or cider for half the water.
If desired, substitute gin in place of the cognac.
If desired, substitute the olive oil with walnut oil for a nuttier taste but be sure to cook on low heat and very quickly.
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Column chromatography eluting with CH2Cl2 to CH2Cl2/MeOH (95:5) afforded the desired substituted 6-phenylpyrazine-2,3-diamine, which was used for subsequent reaction without further purification.
Concentrations higher than 5 mM were found to be inhibitory for optimal transformation and inoculum size greater than 2% v/v adversely effected the production of the desired substituted catechol.
Finally, reaction of nitrogen nucleophiles 3 with N-benzoyl-α-amido sulfones in the presence of basic catalyst KOH in CH2Cl2 at room temperature afforded the desired N-substituted benzamides 5 bearing 1,3,4-oxadiazol group [Additional file 1].
Finally, reaction of 408 with chlorophosphoramidate 340 in the presence of t-BuMgCl followed by removal of the two THP groups in AcOH afforded the desired 7-substituted 7-deaza-adenine nucleoside prodrug 409 (Scheme 118).
28 Subsequently, the reaction of 3 with two equivalents of KN(SiMe3)2 (KHMDS) cleanly produced the desired iminophosphorano-substituted donor 4, though it could only be isolated in low yield (12%%) owing to its poor solubility.
If desired, you can substitute a chopping board with a sturdy cookie sheet/baking tray or even a serving tray.
gives the desired result after substituting the corresponding expressions and letting and.
Reconstructed liver has been desired as a liver substitute for transplantation.
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