From a pharmacological perspective, it raises the intriguing possibility that specific compounds could be developed, which block the activation of an undesirable signalling pathway at a single chemokine receptor but leave intact the ability to activate a desirable signalling pathway.
However, it is now clear that in addition to the inhibition of G-protein signalling, it is desirable that ligands to these two receptors are also able to activate arrestin signalling which appears to provide cardioprotection [ 66].
Furthermore, a desirable mitoKATP agonist should be active at very low concentrations, preferably less than the micromolar range necessary for DZX to activate mitoKATP.
(To activate: scroll, select, click).
Time to activate the PODs.
I reached up to activate the roof.
Tap once to activate C.I.A. briefing.
There are three ways to activate it.
It is highly desirable to design ligand-dependent transcription regulation systems based on transactivators unresponsive to endogenous ligands but induced by synthetic small molecules unable to activate endogenous receptors.
Additional steps to activate EDGE.
