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Advanced GEM models with multiple genetic abnormalities, able to generate both hormone sensitive and insensitive tumours and in which metastasis occurs at clinically relevant sites will also be a desirable refinement [ 376, 377].
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Mesh refinement is desirable for an advantageous use of the finite-difference time-domain (FDTD) solution method of Maxwell's equations, because higher spatial resolutions, i.e., increased mesh densities, are introduced only in sub-regions where they are really needed, thus preventing computer resources wasting.
(5) and (6), though further refinements are desirable based on time-varying magnetospheric conditions.
Not surprisingly, the standardized root mean residual (SRMR) model fit statistic at the clinical area level was larger than desirable, indicating that further scale refinement could result in stronger factor loadings and a better fitting model at the clinical area level without sacrificing integrity of measurement at the individual caregiver level.
A key difficulty is that stakeholders typically convey their goals indirectly through intuitive narrative-style scenarios of desirable and undesirable system behaviour, whereas goal refinement methods usually require goals to be expressed declaratively using, for instance, a temporal logic.
Forth, although we estimated enthusiasm using two questions with satisfactory internal consistency reliability, as described in the Methods section, there is no standardised method to measure enthusiasm, so more refinement in this direction is desirable.
The microstructural refinement of squeeze cast products is desirable for many critical applications.
From an animal-ethical point of view, a refinement of the procedure is highly desirable.
Constructing CG within the DG framework allows CG to benefit from the desirable properties of DG such as, easier hp-refinement, better stability etc.
Despite of the advantages of such simulation experiments (which allow an exact assessment of the performance of the inference and refinement algorithms), results on biological data are highly desirable, as such data may prove quite different from what was generated in our simulations.
Additional refinement of these genomic resources, as described below, is highly desirable and will be sought in the near future, but the current picture is greatly enhanced relative to our first report [ 3].
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