Tighter pooling may also be desirable during hypothesis generation and study planning to allow more powerful and accurate data mining (Steps 1 3).
The spectrum of cross-study data pooling scenarios varies along at least two axes: A broad scope of pooling is usually desirable during hypothesis generation, feasibility analysis, and proposal development and approval (Steps 1 3 of the ancillary study workflow described above and shown in Table 1).
The Baconian conception of theory is not the only misconception of theory that students are likely to have, and "theory" is not the only term for which such a constructivist approach is necessary and desirable: consider "observation," "hypothesis," "law," "prediction," "test," and indeed "science," as well as the ways in which they interact with one another and with "theory".
The development of computational methods for identifying potential risks associated with chemicals is desirable for generating testable hypothesis to accelerate the hazard identification process.
These desirable changes support the hypothesis from epidemiological data that reducing A1C can improve some medical outcomes even in this high-risk population.
Analog studies in other types of carcinoma would be desirable to validate the hypothesis that impaired lymph node macrophage polarization is a general principle of tumor progression or special to oral squamous cell carcinomas.
The unrooted tree suggests that the invertebrate Aurora-B kinase family evolved prior to the invertebrate Aurora-A kinase family although further examples from other species are desirable to confirm this hypothesis.
But using group selection as a source of hypotheses for desirable traits and goals for breeding is an approach that has not yet been explored.
In addition, many plausible scientific hypotheses may exist about which connections are changed by experimental manipulation, and a formal procedure for directly comparing these competing hypotheses is highly desirable.
Under this hypothesis, it is highly desirable to develop a query tool that can automatically recognize a subset of conditions under which the query gene and its targets share tightly correlated expression profiles.
