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Consequently, lung-specific biomarkers, indicating epithelial cell activation or damage, produced by distinct regions of the respiratory tract, are desirable for evaluation of smoking exposure, effects and identification of susceptible individuals to smoking.
The Dutch recognition system accepts that RCTs are often not applicable or not even desirable for evaluation of certain health promotion interventions, and recognition is not dependent on RCT-based evaluation research.
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A biomarker reflecting long-term past smoking exposure is desirable for accurate evaluation of smoking cessation and for assessment of smoking-related disease risk (CDC 2010).
Therefore, it is highly desirable to develop a simple, cost-effective, and rapid method for evaluation of IAV genetic variability.
Moreover, in pragmatic trials, it is still desirable and often possible to blind the assessor or obtain an objective source of data for evaluation of outcomes.
Additionally, repeated or even routine biomonitoring may be desirable for the efficiency evaluation of risk management options and efficacy of environment and health policies.
However, Sakata et al. reported that in some radioligands, there were considerable differences in organ dose or kinetics between human and animal experiments and that a whole-body PET study would be desirable for the initial clinical evaluation of new PET radioligands [6].
Facultative elongation is desirable for tolerance of SF conditions.
For the evaluation of soil quality parameters it is desirable to select indicators that are directly related to soil quality (Wang and Gong 1998).
Consequently, a model system for systematic evaluation of all stages of NDD with high sensitivity, high resolution, and low cost is highly desirable.
Non-randomized observational trial designs are increasingly used for the evaluation of quality improvement and/or practice-based interventions where rigorous and high fidelity interventions are not feasible or desirable [ 15, 16].
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