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In contrast, antibodies like mouse anti-mouse TNF-alpha are expected to avoid host responses and are desirable for efficacy assessments in mouse disease models and early safety studies.
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Thus the design of therapies that simultaneously improve effective tumor immunity and counteract immune evasion by tumors seems most desirable for clinical efficacy.
To describe the characteristics of short interfering double stranded RNA (dsRNA) against hepatitis C virus (HCV) and to find out the determining factors in design for desirable inhibitory efficacy.
Since there are many RLuc8 molecules on the QD surface which cover the majority of the QD surface area, it remains to be tested whether there will be enough space left to attach enough ligands for desirable targeting efficacy.
As a classical TCM prescription for stroke, Buyang Huanwu Decoction (BYHWD) shows substantial neuroprotective, pro-angiogenic and function-improving effects in animal models of focal cerebral ischemia [ 20- 22], while also possessing desirable clinical efficacy for both hemorrhagic and ischemic stroke [ 23].
Thus, a molecule with superior efficacy is desirable for use an antifibrinolytic agent.
Although a favorable finding in this outcome is most desirable, the measures used are much less precise than those for efficacy and adverse effects.
In addition to efficacy, it is desirable for an insecticide to have a high selectivity for its target pests in order to minimize environmental impact, and to conserve biological control services provided by other organisms residing in the treated area.
It is desirable to test the selected AOs targeting human dystrophin exons in animal models for efficacy as part of AO drug development.
Is there evidence for efficacy any stronger?
Advertisers pay for efficacy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com