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Only by government regulation can we get to the obviously desirable endpoint within any reasonable time frame; and of course as LEDs get manufactured in every-greater numbers, the unit cost will go down, further underlying the validity of the phaseout policy.
While using fewer unnecessary antibiotics is a desirable endpoint, it may also be achieved by careful and serial clinical evaluation, using the Clinical Pulmonary Infection Score.
Although symptom resolution is a desirable endpoint of any therapy, it is problematic in EoE where symptom resolution correlates poorly to other important endpoints, such as histology.
The finding in the current study of no difference by diagnosis was a desirable endpoint in that items were deliberately and systematically selected to apply across diagnoses and to minimize egosyntonic responding.
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There have been no published studies that have investigated levels of pressure on desirable endpoints such as reduction of haematoma or seroma, reduction of oedema, increase in wound strength or reduction in complications.
This goes some way towards satisfying another desirable characteristic of surrogate endpoints, namely, that they should relate linearly to the true endpoint.
Overall, propranolol seemed to be the most desirable intervention when several endpoints were simultaneously considered (Fig. 11).
It is desirable to have a clinical endpoint like the Medical Research Council MRCC) scale for muscle strength to assess the course of CIPNM.
When the primary objective of a trial involves more than one efficacy endpoints it is desirable to extend the two-stage design to a setting that accommodates two hypotheses while controlling overall type I and II errors (α and β).
Developing readily measurable biomarkers to accurately predict and report these endpoints is therefore desirable.
Even then, long-term follow-up data with either cancer-specific death or onset of castration refractory disease as an endpoint would be highly desirable.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com