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In order to strike a compromise between the responses, the function of desirability was applied by using Design Expert software version 7.1.5.1 (STAT-EASE Inc., Minneapolis, USA).
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Multi-criteria decision-making (Derringer desirabilities) was applied to balance resolution and analysis time.
A desirability function was applied to combine these two indexes as a single objective function.
A desirability function was applied to combine these two qualities as a single objective function.
A multi-response optimization based on a desirability function was applied to optimize the derivatization.
The desirability function was applied to determine the best process parameters and predict the responses, which were confirmed experimentally.
Desirability function was applied to determine the best process parameters and to predict the responses, which were confirmed experimentally.
Considering the large amount of information, often not convergent, a global desirability function was applied for multi-responses optimization.
Desirability function was applied in this stage to maximize sugar yields and minimize inhibitor concentrations, resulting in overall sugars yield ∼60% and furfural concentration of 0.5 g/L.
For the improvement of method development and optimization step, Derringer's desirability function was applied to simultaneously optimize the five chosen responses.
Derringer's desirability function was applied to simultaneously optimize the retention time of last eluting peak (ketorolac tromethamine) and tailing factor of moxifloxacin.
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