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Conforming to the minimization of erosive wear at desirability equal to 1: 4.67% by weight HNT composition, 0.9235 bar pressure, and 900 impingement angle, a wear rate of 0.0391x10-5g/g is found.
In the prospective analysis, an LL equal to 1.0 was transformed into a desirability equal to 0.5.
A post hoc analysis was also performed using more stringent criteria, where an LL equal to 1.5 was transformed in desirability equal to 0.5 (applied only for A strains).
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Optimum formulation obtained according to overall acceptability, cooking yield, frying loss and hardness contained 2.216% RS, 1.328% BG and 2.456% ST with desirability equals to 0.878.
Therefore, if either of the individual desirability values is equal to zero, then the overall desirability is equal to zero.
With LLOQ equal to 0.03 µg/ml, the desirability value was high and robust to any change of the other design elements, within the range envisaged.
With LLOQ equal to 0.1 µg/ml, the desirability index decreased; it became more sensitive to baseline CRP values and could be improved by an (undesirable) increase of the number of subjects.
The highest level of desirability was obtained for the combination with a Cohort 2 dose equal to 3 mg/kg.
In principle, it should be possible to re-engineer β-lactams to bind PBP2′ strongly, and the desirability of this approach is self-evident: no other antibiotic class has a record equal to the β-lactams for safety and efficacy.
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