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JMP defined piecewise smooth functions for desirability based on the default settings.
Besides the Desirability based duplex optimization in RSM, the Taguchi method has been employed for mono-objective optimization of Esp and Ra.
In the post hoc model, a higher AS03 dose, but not MPL, increased the desirability based on HI responses against both of the influenza A strains.
The model also indicated that whereas inclusion of MPL appeared to increase desirability based on HI responses against the B/Malaysia strain, no clear effect was shown for the A/Solomon Islands H1N1 and the A/Wisconsin H3N2 strains.
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Finally, a desirability analysis based on the smallest predicted time interval between peaks enabled to find optimal conditions only with ethanol based-mobile phases.
In sum, the method of desirability function based on a neural network was a useful tool to optimize several responses for fermentative hydrogen production processes simultaneously.
Moreover, a desirability analysis based on the final QSAR model showed that to be a useful way of selecting the predictive variable level necessary to obtain potent bisbenzamidines.
Optimum combination (velocity 1054.8 mm/s, abrasive size 8.5 nm, concentration 2.45%) identified using desirability approach based on the second order regression model resulted in Ra value as low as 5.7 nm, well within permissible error limits from the predicted value.
The extraction variables such as the ratio of plant leaves to solvent (1 9), extraction temperature (73 °C) and time (1.9 h) were optimized by the desirability, 0.85 based on the three levels and three factors of Box Behnken design.
The maximum substrate degradation efficiency of 95.3%, hydrogen yield of 305.3 mL/g glucose and average hydrogen production rate of 23.9 mL/h were all obtained at the optimal temperature of 39.0 °C, initial pH of 7.0 and glucose concentration of 24.6 g/L identified by the method of desirability function based on a neural network.
Finally, a desirability analysis based on the smallest time interval between two consecutive peaks and on the overall analysis time, allowed us to achieve, for the first time in CE, full resolution of all 19 PAHs in less than 18 min.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com