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We list the best designs we identified to accommodate 4⩽k⩽9 experimental factors.
From 103 designs, we identified one, named DS-SOSIP.4mut, with four additional mutations at the interface of potentially mobile domains of the prefusion-closed structure.
Of the 21 cohort designs we identified, only 1 was assessed as having a low risk of bias.
39 As to experimental designs, we identified five group studies, 33, 35, 38, 40, 41 with four comparing an EL approach with a no-treatment condition, or an EF condition in a counterbalanced within-subject design.
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Using structure-based drug design, we identified a novel series of 5,6-dihydroimidazolo[1,5-f]pteridine 5,6-dihydroimidazolo[1,5-f]pteridine 5,6-dihydroimidazolo[1,5-f]pteridine
Study design: We identified 66 case reports and case series of delayed interval delivery published between 1880 and 2002.
STUDY DESIGN: We identified women in a database of commercial insurance beneficiaries who underwent cesarean delivery and who were opioid naive in the year prior to delivery.
Through iterative synthesis and analog design, we identified compounds with improved biochemical RORc inverse agonist activity and RORc cellular potencies.
Using parallel synthesis supported by structure-based drug design, we identified peptidemimetic FVIIa/TF inhibitors (compounds 4 11) containing l-Gln or l-Met as the P2 moiety.
Study design: We identified a population of 193 infants who met our case criteria for CLD whose birth weights were ≤1500 g.
Using structure-based drug design, we identified and optimized a novel series of pyrimidodiazepinone PLK1 inhibitors resulting in the selection of the development candidate TAK-960.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com