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This evolution in cancer treatment has triggered the development of innovative trial designs to validate these new hypotheses.
Whereas Collier et al used a single, flat-surfaced anatomic modular knee (Depuy, Warsaw, Indiana), the measurements in the current study were applied to five different implant designs to validate our measurement technique as a more generic application to different implant models.
Official regulatory guidance about appropriate study designs to validate companion diagnostics together with new drugs is still sparse, although both the FDA and European Medicines Agency EMAA) have established procedures, in which applicants may negotiate the amount of evidence required for marketing authorization in this setting (European Medicines Agency 2012).
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This blind validation is designed to validate the results that were presented here.
But it is a self-congratulatory screed designed to validate the converted, not engage the unconverted.
As mentioned in the Methods section an internal control program was designed to validate the homology models used.
The episodes that jump rapidly between lands and perspectives seem designed to validate one type of viewer and to pleasantly scramble the other.
They're both designed to validate their audience and vilify their opponents, echoing a dozen Twitter arguments unfolding at this very moment.
This study was designed to validate Modified Breast-GPA.
However, few works have been designed to validate their correctness.
We describe three studies designed to validate this device.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com