Sentence examples for designs of interactions from inspiring English sources
The three layer mitogen activated protein kinase (MAPK) signaling cascade exhibits different designs of interactions between its kinases and phosphatases.
Here, we built computational models of four experimentally observed designs of interactions among the kinases and phosphatases of the MAPK cascade and compared the robustness and signal response behavior associated with each of the designs.
We found that irrespective of the parametric differences in K1 and K2 type models, the MAPK cascade's robustness and signal response behaviour are pivotally shaped by the designs of interactions among its kinases and phosphatases.
To elucidate the generalized nature of behaviors emerging pivotally from the different designs of interactions among kinases and phosphatase in the MAPK cascade, we carried out our studies adopting both steady state kinetics (K1) and elementary mass action kinetics (K2).
We further showed, when the models were activated by transient signal, memory (total time taken by the cascade output to reach its unstimulated level after removal of signal) of a cascade was determined by the specific designs of interaction among its kinases and phosphatases.
Our research and design process both informs the design of interactions with computational systems and leads to new knowledge about the relationships between the body, the digital medium, and cognition (in particular, spatial cognition).
Protein protein interactions play critical roles in biology, and computational design of interactions could be useful in a range of applications.
A typology for the identified relationships is developed, offering a helpful basis for the purposeful planning and design of interactions aimed at developing co-capability.
Objective: This paper presents a framework for the design of interactions between human and computational agents working in organisations, mediation by technological systems.
Design: The design of interactions within an organisation is viewed from the point of view, not of the technology mediating the new interaction, but of the human and computational agents who interact with each other.
