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With the emergence of MTAs, early phase trials have evolved into complex studies, and trial designs have changed with it.
Instrumental designs have changed greatly over the last few years solving many of the initial instrumentation challenges.
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Over time, the scope and objectives of the urban design have changed.
That was nearly 70 years ago, and design has changed dramatically since then, as the designer Tim Brown relates in his new book, "Change by Design".
The basic high-topped sneaker design has changed little since.
The more automobile design has changed, the more it has remained the same.
Plenty of ranchers still swear by the machines, whose design has changed little in a century.
Little of the design has changed since it was unveiled at the 2008 Detroit auto show.
In Iraq, the colors have endured through the decades, but the design has changed again and again -- most recently last week -- like chapter headings in a tempestuous history.
"The field of decorating and design has changed radically in the last 20 years," said Paige Rense, editor in chief of Architectural Digest for the last three decades.
Lynn Felsher, the curator of textiles at the Fashion Institute's museum, notes that textile design has changed radically since the 50's.
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