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Theoretical analysis of mainsprings is notoriously difficult, and they are usually designed using well established rules of thumb.
The discretization for the tempered fractional substantial derivative is derived, and the corresponding finite difference and finite element schemes are designed with well established stability and convergence.
To our knowledge, at the time the data was produced and analyzed, although different tools were being developed for SNP discovery, none of them were specifically designed or well established for calling SNPs from 454 data on homozygous diploid crop lines.
The use of gradient-based optimization algorithms in inverse design is well established as a practical approach to aerodynamic design.
It's true that there have been some technical innovations, but the mechanics of passive solar design were well established 30 years ago.
The use of blending and filleting operations in solid modeling and computer-aided geometric design is well established.
The possibility to shape the micromorphology properties of layered double hydroxides can contribute in designing and obtaining well established nanoporous properties for these materials.
In some ways, robust design appears to be similar to damage tolerant design but its application to aerospace structural design is neither well established nor understood.
The problem is basically in the code design for multilevel signal sets using binary codes on which design methodology is well established.
When this trial was designed, these data were not well established and the weekly D schedule was chosen because of its low toxicity profile.
There are well established design patterns that introduce redundancy and that are widely documented and adopted by the industry.
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