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In further prospective, well designed trials are needed.
The duration that the therapeutic effect continues should be studied in future well designed trials.
More carefully designed trials and long-term follow up studies should be developed.
The more recent and better designed trials have failed to demonstrate the benefits of operative treatment.
Rigorously designed trials are needed to confirm the evidence.
Future work will focus on appropriately designed trials to elucidate the operating mechanism linking EM, depression, and CM onset.
Similar(20)
Without well-designed trials, such assessments are largely guesswork.
"Were we to insist that all, or nearly all, procedures be studied in well-designed trials, we could answer many critical clinical questions," Dr. Lauer wrote.
Few well-designed trials have evaluated the acute pharmacologic management of migraine in children [9, 10].
Large and well-designed trials are still needed.
These preliminary findings need to be further explored by larger well-designed trials.
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