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Photodynamic therapy (PDT) can be designed to target either tumor vasculature or tumor cells by varying the drug-light interval.
The siRNAs were designed to target either thymidine kinase (TK) or DNA polymerase (DP) genes, which both code for transcripts involved in DNA replication.
Therefore, specific treatment approaches could be designed to target either early PC or advanced PC.
Current endocrine therapies for ER-positive breast cancers are primarily designed to target either estrogen or ER levels and/or activity.
Another key point is that current programs are designed to target either substance use or mental health disorders, despite research indicating that these disorders co-occur [ 2].
It has been suggested that drugs designed to target either EGFR or HER2 would be effective at least in HER2 amplification patients; however, EGFR and HER2 do not always show high gene copy number or high protein levels at the same time.
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Recent reviews by Huber and Groll [ 24], and Kisselev and colleagues [ 7] summarized chemical and crystallography data of BTZ and second-generation PIs designed to target and bind either reversibly or irreversibly to constitutive and/or immunoproteasomes.
The non-polymorphic (CN) probes were designed to target DNA either from both enzymes or NspI exclusively, but not from StyI alone.
This therapy is designed to target ER either by using ER modulators or by inhibiting the endogenous synthesis of 17β-estradiol with aromatase inhibitors.
Lastly, the use of allele-specific siRNAs, designed to target preferentially either the mutant or the wild-type KRAS allele, further serves to illustrate the dependence of the KRAS mutant cells on the activated KRAS allele for the suppression of pro-apoptotic signaling (Supplementary information, Figure S1E and S1F).
However, each method is designed to target only one cytoskeletal network, either the microtubule (MT) or actin cytoskeleton, and non-targeted cytoskeletal networks are ignored.
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