Sentence examples for designed to reactivate the from inspiring English sources
show that a combination therapy designed to reactivate the p53 tumor suppressor while antagonizing the anti-apoptotic function of Bcl-2 is highly active in preclinical models of refractory acute myeloid leukemia (AML).
This study was undertaken to examine the effects of systemic cycloheximide and anisomycin treatment on the reconsolidation and maintenance of a reactivated cocaine-conditioned place preference (CPP) in mice using several strategies designed to reactivate the previously acquired memory.
These data indicate that in addition to direct tumor cell killing, new targeted therapy might be also designed to reactivate the body's immune response against tumor cells.
As epigenetic silencing of the MLH1 promoter is commonly seen in tumours showing acquired resistance (Herman and Baylin, 2003), our work also suggests that combining strategies designed to reactivate the silenced MLH1 (such as treatment with DAC; Plumb et al, 2000) with SN1 methylating agents may promote PARP-mediated cell death.
This suggests that immune enhancing strategies may need to accompany therapies designed to reactivate HIV-expression in latently infected cells, but the extent of induced virus production should also merit consideration.
In conclusion, our strategy unveils the limitations of the targeted action of a small molecule designed to reactivate mutant p53.
Cytotoxic drugs, such as cisplatin, are designed to reactivate apoptotic pathways by inducing stress pathways, such as via p38, or by suppressing MAPK/AKT signaling (Winograd-Katz and Levitzki 2006).
The computational study suggests that the newly designed oxime is a potential candidate to reactivate the aged-AChE adduct.
Dimethyl(pyridin-2-yl)sulfonium based oxime has been designed to reverse the aging process of organophosphorus inhibited AChE and to reactivate the aged-AChE adduct.
For weeks BP tried without success to reactivate the seal-off valves on the dead blowout preventer, the tower of pipes designed to shut the well.
The reactivation group mice are exposed to the experimental chamber to reactivate the fear memory.
