Sentence examples for designed to reactivate from inspiring English sources

In conclusion, our strategy unveils the limitations of the targeted action of a small molecule designed to reactivate mutant p53.

show that a combination therapy designed to reactivate the p53 tumor suppressor while antagonizing the anti-apoptotic function of Bcl-2 is highly active in preclinical models of refractory acute myeloid leukemia (AML).

This study was undertaken to examine the effects of systemic cycloheximide and anisomycin treatment on the reconsolidation and maintenance of a reactivated cocaine-conditioned place preference (CPP) in mice using several strategies designed to reactivate the previously acquired memory.

These data indicate that in addition to direct tumor cell killing, new targeted therapy might be also designed to reactivate the body's immune response against tumor cells.

This suggests that immune enhancing strategies may need to accompany therapies designed to reactivate HIV-expression in latently infected cells, but the extent of induced virus production should also merit consideration.

Cytotoxic drugs, such as cisplatin, are designed to reactivate apoptotic pathways by inducing stress pathways, such as via p38, or by suppressing MAPK/AKT signaling (Winograd-Katz and Levitzki 2006).

This study was designed to investigate whether GSPs reactivate silenced tumor suppressor genes following epigenetic modifications in skin cancer cells.

Recently, new therapies based on sophisticated knowledge of the suppressive tumour immune microenvironment were designed to overcome tolerance and reactivate anti-tumour immunity to induce potent, long-lasting responses (Mellman et al, 2011).

By using a cell-based assay designed to find small molecules with the ability to reactivate an epigenetically silenced locus and turn on its transcription, we have identified 19 validated novel potential transcriptional modulators.

Therefore, drug discovery and development programs in academia and industry have mostly focused on kinase inhibitors and other approaches designed to inhibit activated oncoproteins, whereas relatively few therapeutic strategies to reactivate tumor suppressors have been developed to date.

Dimethyl(pyridin-2-yl)sulfonium based oxime has been designed to reverse the aging process of organophosphorus inhibited AChE and to reactivate the aged-AChE adduct.