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Many groups are exploring the use of bionanoconjugates that can be designed to probe functional biological pathways in living cells, and the identification of pathways important in nanomaterial uptake into cells will facilitate this work.
Twelve analogs were designed to probe functional group tolerance on both the A-ring and B-ring of C-6 as well as the diarylmethine position.
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Growing evidence indicates that, like the bacterial microbiota, the fungal microbiota is often altered in disease states, and increasingly studies are being designed to probe the functional consequences of such fungal dysbiosis on health and disease.
The present study was designed to probe the phenomenon of functional selectivity at the D1 receptor further by testing the hypothesis that structurally dissimilar agonists with efficacies at these endpoints that equal or exceed those of dopamine would differ in ability to influence receptor fate after internalization, a functional endpoint largely unexplored for the D1 receptor.
Anticipating this issue, trial protocols need to include a variety of rating scales designed to probe neurological, cognitive, psychiatric and general functional status.
The occurrence and functional relevance of these motions is verified by cross-linking experiments designed to probe the computationally predicted distance changes.
And the interviews are designed to probe their knowledge deeply.
Further experiments were designed to probe these hypotheses (Table 1).
Workflow to probe functional changes of the gut microbiome.
Future studies could be designed to systematically probe these issues.
MOST sports equipment is designed to be functional first, stylish second.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com