A rigorous systematic search designed to identify robustly implicated factors emerging from methodologically rigorous studies narrowed our search to 13 observational studies (total N=6235) relating to adherence, antipsychotics and schizophrenia.
Understanding the molecular aspects of CRPC evolution has allowed for the development of targeted agents specifically designed to inhibit pathways implicated in the proliferation and growth of malignant cells (Nabhan et al, 2011).
Targeted agents that are designed to abrogate various pathways implicated in signal transduction, cell cycle checkpoints, immunomodulation, and DNA repair offer promising novel approaches for the treatment of metastatic melanoma.
Here we report a novel instrumental learning task designed to determine whether regions implicated in processing reversal errors are uniquely involved in this process, or whether they play a more general role in representing response competition, reinforcement value, or punishment value in the absence of demands for response change.
Using an in vitro model designed to recapitulate cellular events implicated in mycobacterial infection and dissemination in vivo (i.e., phagocytosis of apoptotic macrophages containing mycobacteria), we demonstrated reduced recovery of viable mycobacteria within Cd36 -/- macrophages.
Biologic agents have been designed to target key cytokines implicated in JIA, including TNFα, IL-1, IL-6 as well as signaling molecules involved in the regulation of B-cell and T-cell lymphocyte responses (Table 4).
An intervention designed to specifically address the factors implicated in this study and tailored to meet the needs of Humboldt Park is a warranted and much needed next step to work in this community.
This study was designed to determine whether Notch signaling is implicated in other steps of melanocyte-lineage postnatal development.
Systematic approaches designed to identify schizophrenia susceptibility genes have implicated the chromosome 22q11 microdeletion region as a promising hot-spot [ 1, 2].
