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However, current therapies are designed to impair carcinoma metastasis mainly by impairing initial dissemination events.
The conditions designed to impair circulation in the teat barrel also had a deleterious effect on circulation at the teat end.
A series of Dox analogs with bulky substitutions at the C-4′ at amino-sugar have been designed to impair interactions between the drug and P-glycoprotein (P-gp), a multidrug drug resistance (MDR) transporter.
Hjv MO1 targets the 5' UTR of hjv and is designed to impair translation of hjv, while hjv MO2 is a non-overlapping morpholino targeting the second exon donor site of the coding sequence.
These genes and their promoters would not be useful for generation of Medea elements, but their transcription units could be interesting targets for homing endonucleases designed to impair female fertility.
The prolonged exposure to multikinase inhibitors, which target the intracellular pathways downstream VEGF, PDGF, and EGF receptors, might "silence" the ability of metastatic cells to respond to endogenous growth factors [ 60], albeit the treatment was designed to impair endothelial signalling.
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The military said it was designed to "severely impair the command and control chain of the Hamas leadership".
Because the sigma-2 (σ2) receptor was recently proposed as a promising target for pancreatic cancer therapy, we explored our previously developed multifunctional thiosemicarbazones, designed to synergistically impair cell energy levels, by targeting σ2 and P-gp proteins and chelating Iron.
In 2010, British Columbia (BC) introduced new traffic laws designed to deter impaired driving, speeding, and distracted driving.
The [35S]TBPS binding assay was designed to reveal impaired GABA and channel site coupling shown to be more prominent in recombinant α1/6β3 than in α1/2β3γ2 or β2 subunit-containing GABAA receptors expressed in HEK 293 cells.
Testing of the reliability in children with prosthetic hands and other hand impairments because the SHAP was originally designed to evaluate unimpaired, impaired, and prosthetic hands.
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