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We have tested this proof-of-concept by using ODC peptides that are designed to be cleaved only by TNKase and are resistant to cleavage by enzymes present in the plasma and the tumor.
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This spacer is designed to be cleaved in the reducing milieu of the cytoplasm and thus decrease lipid toxicity.
To test this hypothesis, antigen-adjuvant conjugates were designed to be cleaved by an intracellular trigger to release antigen and adjuvant from each other.
Cleavable linkers are designed to be cleaved by responding to an environmental difference between the extracellular and intracellular environments (pH, redox potential, etc).
To accomplish this holistic program, his "design revolution" had to be cleaved from political connotations, and technologically determined functionalism substituted for the vicissitudes of political action.
Korea was hardly the only country to be cleaved in two by politics and conflict during the 20th century.
He's about to be cleaved in two by a roaring, bearded behemoth, only for the behemoth to pitch forward, speared in the back by our hero's equally handsome sidekick.
Only a limited number of distinct substrates seem to be cleaved.
However, only 33 PKs were cleaved by CASP3; therefore, to be cleaved by CASP3, the DXXDX sequence and a structural element –probably accessibility – are required.
Besides the BH3-only proteins, keratin 8 has been reported to be cleaved in cells infected with C. trachomatis [31].
These derivates were not intended for the design of a future library, as they could not be cleaved for evaluation, but were used only to test this hypothesis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com