Sentence examples for designed to be activated from inspiring English sources
Designer receptors based on the muscarinic M3 and M4 subtypes were designed to be activated by clozapine-N-oxide (CNO), a ligand previously shown to be an inert metabolite of clozapine.
This prodrug was designed to be activated by glutathione (GSH) to release NO.
CASP3* is designed to be activated specifically by HIV-1 protease; thus, it offers a basis for a novel therapeutic approach with few "off-target" effects.
Specifically, DNAzymes are designed to be activated after recognition between the target protein and its aptamer, pre-hybridized with a DNAzyme sequence.
These prodrugs are designed to be activated by ubiquitously expressed phosphatases with much improved chemical stability and reduced acute toxicity profile.
Here, a mutant of CASP3 designed to be activated specifically by the aspartate protease of human immunodeficiency virus type 1 (HIV-1), but not by other CASPs, was produced (CASP3*) and a proof-of-concept study was conducted to demonstrate the therapeutic potential of CASP3* against lymphoid malignancies and HIV-1 infection.
A novel 5-aminolevulinic acid (5-ALA) prodrug was custom-designed to be activated selectively by endogenous Cath E within the PDAC cells.
PABA/NO [O2-{2,4-dinitro-5-[4- N-methylamino benzoyloxy]phenyl} 1-(N,N-dimethylamino) diazen-1-ium-1,2-diolate] is a nitric oxide (NO)-releasing arylating agent designed to be selectively activated by reaction with glutathione (GSH) on catalysis by glutathione S-transferase P1 (GSTP1), an enzyme frequently overexpressed in cancer cells.
There was no signal from the plane's emergency locator transmitter (ELT) designed to be automatically activated in the event of a crash, but it was of an older type notorious for failing to operate after a crash.
For this purpose, we used a murine αGalT (mαGalT) transgene driven by a form of p Neu designed to be significantly activated in breast tumor cells.
As a triple prodrug, capecitabine is designed to be sequentially activated to 5-FU: capecitabine is hydrolysed in the liver to 5′-deoxy-5-fluorocytidine, which is then converted into 5′-deoxy-5-fluorouridine (5′-dFUR) and subsequently into 5-FU by thymidine phosphorylase.
