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The study was originally designed to accrue a maximum of 82 patients with an interim analysis after 53 patients.
The study was designed to accrue a minimum of 20 patients to have adequate precision to estimate the true overall response rate.
CV outcome studies to address the requirements of the 2008 FDA guidance (11) are typically event-driven, i.e., designed to accrue a predefined number of end point events.
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The study was originally designed to accrue, in a single-stage design, 25 patients assessable for response allowing the CR rate to be estimated with a standard error of ⩽10%.
Its often knotty procedures are designed to accrue powers to the central authority while moderating the authority of pre-existing nations.
Although initially designed to accrue 120 patients, this trial was stopped after 85 patients due to slow accrual.
The trial was designed to accrue 60 patients (plus 5% drop-out reserve) with glioblastoma and to detect an improvement of the PFS-12 of 15.6% as compared to the data of the EORTC26981/NCIC-CE.3 (radiotherapluslus concomitant and adjuvant TMZ) arm (PFS-12: 26.9%) with an α error of 0.10 and β error of 10%.
However, the broker needs the request to be executed for 2500 s to accrue a profit.
Furthermore it would be impossible to accrue a sufficiently large material of patients with unruptured aneurysms.
The study was expected to accrue a minimum of 12 and a maximum of 60 patients.
This study aims to accrue a total of 99 patients within four years.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com