We believe that carefully designed proof-of-concept studies are indicated to ensure that pathogenetically useful information at least is obtained.
However, it is in Phase II that well designed proof-of-concept studies using such measures could help provide robust signals of proof-of-mechanism or early safety signals.
We develop and model the device physics to understand the physical underpinnings of the raw device data and then use these models to design proof-of-concept experiments to verify device function.
A possible solution to this dilemma is to design proof-of-concept studies to explore whether a therapy demonstrates consistent indications of a possible clinical benefit for multiple endpoints that are relevant to the disease.
This paper presents the design, proof-of-concept implementations and experimentation of the Health Surveillance Software Framework HSSFF).
Thereafter carefully-designed proof-of-concept phantom experiments are carried out to qualitatively confirm the predicted SNR behavior.
To further validate the conceptual designs, proof of concept prototypes have been constructed.
Ground level: North Carolina State University researchers have designed this proof-of-concept wireless charger for moving electric vehicles.
We designed a proof-of-concept demonstration that obstructed direct-solar irradiation, diminished diffuse-solar irradiation, maximized emission in the atmospheric window, reduced infrared absorption, and minimized heat gain due to conduction and convection.
The extension consists in the description of the interaction with the Cloud resources, as well as a the functionality of the tool designed as proof-of-concept.
