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This immunoassay was designed on the rationale that PrP aggregates might be expected to display multiple copies of an epitope recognised by an anti-PrP monoclonal antibody while monomeric PrP protein will have only one copy of the epitope exposed [ 52].
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It has been shown that the persistence of high Ag levels leads to deletion of Ag-specific BMEM (Hausl et al, 2005) and protein-based ITI protocols for inhibitors-positive haemophilic patients are designed on this rationale.
A behavior therapy for alcoholism was designed based on the rationale that alcoholic drinking is a discriminated, operant response.
This treatment protocol was designed based on the rationale that the noninvasive method of intranasal administration can be performed on-site to patients without much delay.
Here, the authors report on the rationale, design, practical implementation and outcome of a new program that was developed at the University Gastroenterology Fellowship Training Program.
That means NIH will be able to include "review criteria that focus on the rationale, design, and operational and analysis plans," such as whether sample sizes are adequate, the JAMA article explains.
From the original study, all 35 to 66 year-old participants were invited to participate in the psychiatric arm of the study; for more details on the rationale, design and methods of the study see Preisig [32].
This paper presents detail on the rationale, design, methods, and operational aspects of the trial.
The research tools provide details on the rationale, design, implementation and funding of these reforms, all of which were important to 'protect the investment' in FHCI.
This article reports on the rationale, design, and methods of a federally funded, multi-site clinical trial focused on management of metabolic adverse effects among youth who require ongoing antipsychotic medication treatment to maintain psychiatric stability.
This paper focuses on the rationale, design, methods, and description of the response rate of the CHIS.FU study, with special emphasis on efforts to update the address and vital status of the participants that took place before the follow-up interview as well as a description of the different techniques that were used to improve the response rate.
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