GWAS, which are designed on the common disease-common variant hypothesis (CD-CV), identified several SNPs and loci for complex phenotypes.
A series of new isatin/triazole conjugates were designed based on the hypothesis that the ester-linked compounds could be enzymatically hydrolyzed by cellular esterases inside the cells.
Computerized exercises were designed based on the hypothesis that repeated task-dependent coactivation of multiple DMN regions would translate into regulation of resting-state network connectivity.
This study was designed based on the hypothesis that members of the genus Pseudomonas given their high prevalence, wide distribution in waters and genetic plasticity can be important reservoirs of antibiotic resistance in drinking water.
New chiral ligands (4 and 5) for polymetallic asymmetric catalysts were designed based on the hypothesis that the assembled structure should be stable when made from a stable module 8.
The NURHI initiative was designed based on the hypothesis that when demand for family planning rises, supply will rise to meet the demand over time.
We based our design on the hypothesis that an accurate predictive model may need several markers, and that markers closer to the malignant phenotype (activated, phosphorylated proteins) may be better predictors than DNA/RNA markers or inactive (unphosphorylated) protein markers.
We chose to use 17 rather than all of the nucleotides of the miRNA for primer design based on the hypothesis that four or fewer nucleotides flanking the last nucleotide in the predicted miRNA would vary, thus maintaining at least 75% identity between the primer and the miRNA orthologs, consistent with the conservation reported for cloned miRNA homologs.
This experimental design relies on the hypothesis that these motifs are present in the genomic copies of the RP genes, in the same position as it lies in their transcripts.
This was a noninferiority study design based on the hypothesis that the difference in mean daily BG between basal plus sitagliptin and basal bolus regimens would be no greater than 18 mg/dL (1 mmol/L) (11, 14).
